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PYRUVATE DEHYDROGENASE COMPLEX
Descriptors Found:
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DeCS
Descriptor
English
:
Pyruvate Dehydrogenase Complex
Descriptor
Spanish
:
Complejo Piruvato Deshidrogenasa
Descriptor
Portuguese
:
Complexo Piruvato Desidrogenase
Synonyms
English
:
Complex, Pyruvate Dehydrogenase
Dehydrogenase Complex, Pyruvate
Tree Number:
D05.500.562.625
D08.811.600.741
Definition
English
:
A multienzyme complex responsible for the formation of
ACETYL COENZYME A
from pyruvate. The enzyme components are PYRUVATE DEHYDROGENASE (LIPOAMIDE); dihydrolipoamide acetyltransferase; and LIPOAMIDE DEHYDROGENASE.
Pyruvate dehydrogenase complex
is subject to three types of
control
: inhibited by acetyl-CoA and NADH; influenced by the
energy
state of the cell; and inhibited when a specific
serine
residue in the
pyruvate decarboxylase
is phosphorylated by ATP. PYRUVATE DEHYDROGENASE (LIPOAMIDE)-PHOSPHATASE catalyzes reactivation of the complex. (From Concise
Encyclopedia
Biochemistry
and
Molecular Biology
, 3rd ed)
Entry Combination - descr/qualif
English
:
Pyruvate Dehydrogenase Complex
/
deficiency
use
Pyruvate Dehydrogenase Complex Deficiency Disease
History Note
English
:
74(73)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
12205
Unique Identifier:
D011768
Occurrence in VHL
:
Similar:
DeCS